The GP workforce situation has worsened further, as full-time equivalent GP numbers have dropped by 523 since March.
Two in five GPs have suffered from a mental health condition, according to a survey of over 1,000 GPs.
GP leaders in Wales have expressed cautious optimism over news that a number of health board-managed practices are returning to independent status.
Exclusive A GP has been forced to stop out-of-hours work after a medical defence organisation quoted indemnity fees of £5,000 annually for one session a week.
BMA Scotland has elected Dr Andrew Buist to take over as chair of the GP Committee.
Dr Jane Fenton-May, Vice-Chair of Royal College of General Practitioners Wales, said:
"Some practices will close as part of efforts to pool resources, but too many are being forced to shut their doors because the lack of support for general practice means it's simply impossible to keep up with rising patient demand.
"Welsh general practice has the lowest percentage of NHS spend of anywhere in the UK. Wales also has the lowest number of GP training places based on population, which means the workforce can't keep up with demand even when places are filled. This is in the context of excessive workforce pressures driving GPs out of the profession early.
"Until this is addressed it's likely that patients will feel the disruption of practices being forced into closing."
Exclusive Small GP practices are least likely to receive NHS England resilience funding, despite accounting for the majority of closures over recent years, Pulse can reveal.
Exclusive Small practices are least likely to receive NHS England resilience funding, despite accounting for the majority of closures over recent years, Pulse can reveal.